Zoledronic Acid, Injection
What are other names for this medicine?
Type of medicine: bisphosphonate; antihypercalcemic
Generic and brand names: zoledronic acid, injection; Reclast; Zometa
What is this medicine used for?
This medicine is given by IV infusion (slow drip through a needle into a large vein).
Zometa is used to treat:
- hypercalcemia (too much calcium in the blood) caused by cancer
- multiple myeloma (bone cancer)
- bone metastases (spread of cancer).
Reclast is used to treat Paget's disease of the bone.
It may be used to treat other conditions as determined by your healthcare provider.
What should my healthcare provider know before I receive this medicine?
Tell your healthcare provider if you have ever had:
- an allergic reaction to any medicine
- aspirin-sensitive asthma (This medicine may worsen asthma)
- kidney or liver disease
- low levels of calcium in the blood.
Tell your provider the date of your last dental exam and if you are scheduled for dental surgery. You may be at risk of a disease called osteonecrosis of the jaw if you have dental surgery while taking this medicine.
Females of childbearing age: This medicine is not usually given to pregnant women because it can harm the baby. If you are pregnant, tell your healthcare provider. Do not become pregnant during treatment with this medicine. If you become pregnant, contact your healthcare provider right away. Do not breast-feed while you are receiving this medicine.
How do I take it?
These infusions are given by your healthcare provider. The length of treatment with this medicine depends on how you respond to treatment.
Your healthcare provider may want you to take oral calcium and vitamin D while you are receiving this medicine. Do not take these without your healthcare provider's approval. Also talk with your provider about how much water you should drink while taking this medicine.
What should I watch out for?
This medicine may cause kidney problems. You will need regular blood and urine tests to see how the medicine is affecting you. Keep all appointments for tests.
If you need emergency care, surgery, or dental work, tell the healthcare provider or dentist you are taking this medicine.
What are the possible side effects?
Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse
Serious (report these to your healthcare provider right away): Problems urinating, fever, chills, bone pain, muscle or joint pain, lightheadedness, trouble breathing, chest pain, unusual bleeding and bruising, jaw pain, numbness or tingling around the mouth, muscle spasms, sores in mouth or jaw, vision problems, unusual weakness and tiredness.
Other: Nausea; vomiting; diarrhea; trouble sleeping; dizziness; headache; nervousness; depression; swelling in the legs; redness, swelling, rash, or itching at the spot where you had the infusion.
What products might interact with this medicine?
When you take this medicine with other medicines, it can change the way this or any other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:.
- aminoglycoside antibiotics such as gentamicin (Garamycin), tobramycin (Nebcin, TOBI), amikacin (Amikin), and paromomycin sulfate (Humatin)
- diuretics such as bumetanide (Bumex), ethacrynic acid (Edecrin), furosemide (Lasix), and torsemide (Demadex)
- nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Motrin, Motrin IB, Advil, Nuprin), naproxen (Naprosyn, Anaprox, Aleve, Naprelan), ketoprofen, nabumetone (Relafen), indomethacin (Indocin), ketorolac (Toradol), sulindac (Clinoril), piroxicam (Feldene), diclofenac (Voltaren, Cataflam), and oxaprozin (Daypro)
Keep a list of all your medicines (prescription, nonprescription, supplements, natural/herbal remedies and vitamins) with you. Be sure that you tell all healthcare providers who treat you about all the products you are taking.
This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.
Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Do not throw medicine in the trash.
Keep all medicines out of the reach of children.
Do not share medicines with other people.
