Page header image

Guaifenesin/Dextromethorphan/Pseudoephedrine, Oral

What are other names for this medicine?

Type of medicine: expectorant; antitussive; decongestant

Generic and brand names: guaifenesin, dextromethorphan, and pseudoephedrine; Ambifed-G DM; Dimetapp Cold and Congestion; Guiatuss CF; Maxifed DM; PanMist DM; Profen Forte DM; Profen II DM; Protuss DM; Pseudovent DM; Relacon-DM; Robitussin CF; Robitussin Cold and Congestion; Touro CC; Tri-Vent DM; Z-Cof DM

What is this medicine used for?

This medicine is taken by mouth to relieve coughs due to common colds or other chest infections or irritations. Guaifenesin is used to help bring up mucus from the lungs, to thin secretions, and to make a cough productive. Dextromethorphan helps stop excessive coughing. Pseudoephedrine helps clear up nasal and sinus congestion.

What should my healthcare provider know before I take this medicine?

Before taking this medicine, tell your healthcare provider if you have ever had:

  • an allergic reaction to any medicine
  • diabetes
  • glaucoma
  • heart disease
  • high blood pressure
  • thyroid disorder
  • trouble urinating or an enlarged prostate.

Do not take this medicine for coughs caused by smoking, asthma, chronic bronchitis, or emphysema, or if you are already coughing up a lot of phlegm unless your healthcare provider approves.

Females of childbearing age: Tell your healthcare provider if you are pregnant or plan to become pregnant. Do not breast-feed while taking this medicine without your healthcare provider's approval.

How do I take it?

Take this medicine exactly as your healthcare provider prescribes. If your healthcare provider has not given you specific instructions, follow the directions that come with the medicine package. Do not take more or take it longer than prescribed. Ask your healthcare provider or pharmacist about anything you do not understand.

This medicine may come in different forms. If you have extended-release tablets, do not break, crush, or chew them. Swallow them whole. Ask your pharmacist if you have the extended-release tablets.

Drink plenty of water with this medicine to help loosen the mucus or phlegm in the lungs.

What should I watch out for?:

Contact your healthcare provider if your symptoms have not improved within a few days.

This medicine may make you dizzy or drowsy. Do not drive or operate machinery unless you are fully alert.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted effects. The side effects of this medicine are mild and may go away as your body adjusts to the medicine. Tell your healthcare provider about any side effects that continue or get worse.

Serious (report these to your healthcare provider right away): Fast or pounding heartbeat, shortness of breath, chest pain, hives.

Other: Nausea, vomiting, stomach cramps, dizziness, headache, mild rash, drowsiness, trouble sleeping, restlessness, nervousness.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:

  • herbal remedies such as ephedra and yohimbe
  • MAO inhibitor antidepressants such as phenelzine (Nardil), tranylcypromine (Parnate), and isocarboxazid (Marplan) (Do not take a MAO inhibitor and this medicine within 14 days of each other.)

Keep a list of all your medicines (prescription, nonprescription, supplements, natural remedies, and vitamins) with you. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

How should I store this medicine?

Store this medicine at room temperature. Keep the container tightly closed. Protect it from heat, high humidity, and bright light.


This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Do not throw medicine in the trash.

Keep all medicines out of the reach of children.

Do not share medicines with other people.

Developed by McKesson Corporation
Published by McKesson Corporation.
Last modified: 2005-11-02
Last reviewed: 2005-10-24
This content is reviewed periodically and is subject to change as new health information becomes available. The information is intended to inform and educate and is not a replacement for medical evaluation, advice, diagnosis or treatment by a healthcare professional.
Copyright © 2007 McKesson Corporation and/or one of its subsidiaries. All Rights Reserved.
Page footer image